High-serum phosphate and parathyroid hormone distinctly regulate bone loss and vascular calcification in experimental chronic kidney disease

• Published in: Nephrology, dialysis, transplantation Vol. 34; no. 6; pp. 934 - 941
• Main Authors: Carrillo-López, Natalia, Panizo, Sara, Alonso-Montes, Cristina, Martínez-Arias, Laura, Avello, Noelia, Sosa, Patricia, Dusso, Adriana S, Cannata-Andía, Jorge B, Naves-Díaz, Manuel
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2019
• Subjects: Animals; Bone Diseases, Metabolic - blood; Bone Morphogenetic Protein 2 - metabolism; Bone Morphogenetic Proteins - metabolism; Calcitriol - blood; Calcium - blood; Calcium - metabolism; Core Binding Factor Alpha 1 Subunit - metabolism; Fibroblast Growth Factors - metabolism; Genetic Markers; Hyperphosphatemia - metabolism; Kidney - drug effects; Male; Muscle, Smooth, Vascular - metabolism; Myocytes, Smooth Muscle - metabolism; Nephrectomy; Osteogenesis - drug effects; Parathyroid Hormone - blood; Parathyroid Hormone - therapeutic use; Parathyroidectomy; Phosphates - blood; Phosphorylation; Rats; Rats, Wistar; Renal Insufficiency, Chronic - blood; Vascular Calcification - metabolism; Vitamin D3 24-Hydroxylase - metabolism; mineral metabolism; renal osteodystrophy; gene expression; parathyroidectomy; vascular calcification

Abstract Background In chronic kidney disease (CKD), increases in serum phosphate and parathyroid hormone (PTH) aggravate vascular calcification (VC) and bone loss. This study was designed to discriminate high phosphorus (HP) and PTH contribution to VC and bone loss. Methods Nephrectomized rats fed...