Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein

Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid develop...

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Published inChinese physics B Vol. 27; no. 2; pp. 21 - 28
Main Author 缑璐;金桃丽;陈淑玉;李娜;郝东晓;张胜利;张磊
Format Journal Article
LanguageEnglish
Published 01.02.2018
Subjects
动态结构;DNA;脂蛋白;抗体;单个分子;大分子;电子显微镜;动力学模拟
Online AccessGet full text
ISSN1674-1056
2058-3834
DOI10.1088/1674-1056/27/2/028708

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Abstract Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule tech- nologies and cryo-electron microscopy （cryo-EM）, an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.
AbstractList Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule tech- nologies and cryo-electron microscopy （cryo-EM）, an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.
Author 缑璐;金桃丽;陈淑玉;李娜;郝东晓;张胜利;张磊
AuthorAffiliation Department of Applied Physics, School of Science, Xi＇ an Jiaotong University, Xi＇ an 710049, China
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Notes Bio-macromolecules, such as proteins and nucleic acids, are the basic materials that perform fundamental activities required for life. Their structural heterogeneities and dynamic personalities are vital to understand the underlying functional mechanisms of bio-macromolecules. With the rapid development of advanced technologies such as single-molecule tech- nologies and cryo-electron microscopy （cryo-EM）, an increasing number of their structural details and mechanics properties at molecular level have significantly raised awareness of basic life processes. In this review, firstly the basic principles of single-molecule method and cryo-EM are summarized, to shine a light on the development in these fields. Secondly, recent progress driven by the above two methods are underway to explore the dynamic structures and functions of DNA, antibody, and lipoprotein. Finally, an outlook is provided for the further research on both the dynamic structures and functions of bio-macromolecules, through single-molecule method and cryo-EM combining with molecular dynamics simulations.
11-5639/O4
bio-macromolecule, single-molecule method, cryo-electron microscopy, electron tomography
Lu Gou, Taoli Jin, Shuyu Chen, Na Li, Dongxiao Hao, Shengli Zhang, and Lei Zhang（Department of Applied Physics, School of Science, Xi＇ an Jiaotong University, Xi＇ an 710049, China）
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SubjectTerms 动态结构;DNA;脂蛋白;抗体;单个分子;大分子;电子显微镜;动力学模拟
Title Bio-macromolecular dynamic structures and functions, illustrated with DNA, antibody, and lipoprotein
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