10-Secocycloartane (=9,19-cyclo-9,10-secolanostane) triterpenoid saponins: Huangqiyenins M–X from Astragalus membranaceus (Fisch.) Bge

• Published in: Phytochemistry (Oxford) Vol. 222; p. 114072
• Main Authors: Yan, Meng-Qi, Xu, Feng, Kuang, Hai-Xue, Shi, Xue-Peng, Cao, Feng, Yang, Bing-You, Wang, Zhi-Bin
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.06.2024; Elsevier
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Astragalus membranaceus (Fisch) Bge; Astragalus propinquus - chemistry; Biochemistry & Molecular Biology; Cell Proliferation - drug effects; Cytotoxic activity; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fabaceae; HT29 Cells; Huangqiyenins M-X; Humans; Interleukin-2 - metabolism; Life Sciences & Biomedicine; Molecular Structure; Network pharmacology; Plant Leaves - chemistry; Plant Sciences; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Science & Technology; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - metabolism; Structure-Activity Relationship; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; Triterpenoid saponins; Astragalus membranaceus (Fisch) Bge; Network pharmacology; Triterpenoid saponins; Huangqiyenins M-X; Fabaceae; Cytotoxic activity; IMPROVE; CANCER

Phytochemical investigations of the leaves of Astragalus membranaceus (Fisch.) Bge. have led to the isolation of 12 undescribed triterpenoid saponins named huangqiyenins M–X. The structures of the undescribed compounds were determined using NMR and HRESIMS data. The cytotoxicity of these compounds a...