Citric Acid Metabolism in Resistant Hypertension: Underlying Mechanisms and Metabolic Prediction of Treatment Response - Martin-Lorenzo, Marta; Martinez, Paula J.; Baldan-Martin, Montserrat; Ruiz-Hurtado, Gema; Prado, Jose Carlos; Segura, Julian; de la Cuesta, Fernando; Barderas, Maria G.; Vivanco, Fernando; Ruilope, Luis Miguel; Alvarez-Llamas, Gloria (Hypertension (Dallas, Tex. 1979), 2017)
Keywords: Aged; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Antihypertensive Agents - pharmacokinetics; Chromatography, Liquid - methods; Citric Acid - analysis; Citric Acid - metabolism; Drug Resistance - physiology; Drug-Related Side Effects and Adverse Reactions - diagnosis; Drug-Related Side Effects and Adverse Reactions - urine; Female; Humans; Hypertension - drug therapy; Hypertension - epidemiology; Hypertension - metabolism; Ketoglutaric Acids - analysis; Ketoglutaric Acids - metabolism; Male; Middle Aged; Predictive Value of Tests; Prognosis; Spain - epidemiology; Spironolactone - administration & dosage; Spironolactone - adverse effects; Spironolactone - pharmacokinetics; Urinalysis - methods; blood pressure; citric acid cycle; metabolomics; spironolactone; reactive oxygen species