Thioacetamide-induced norepinephrine production by hepatocytes is associated with hepatic stellate cell activation and liver fibrosis

• Published in: Current molecular pharmacology
• Main Authors: Tang, Wei-Chien, Chang, Ya-Wen, Che, Mingtian, Wang, Mei-Hui, Lai, Keith K, Fueger, Patrick T, Huang, Wendong, Lin, Shwu-Bin, Lai, Keane K Y
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.04.2022
• Subjects: norepinephrine; thioacetamide; collagenesis; liver fibrosis; dopamine beta-hydroxylase

Collagen production by activated hepatic stellate cells (HSCs) to encapsulate injury is part of the natural wound-healing response in injured liver. However, persistent activation of HSCs can lead to pathological fibrogenesis. Such persistent HSC activation could be mediated by norepinephrine (NE),...