DMAP‐Catalyzed Efficient Diastereo‐ and Regioselective Synthesis of Isoxazolone‐Based Bisspiroheterocyclic Oxindoles

• Published in: European journal of organic chemistry Vol. 27; no. 48
• Main Authors: Zhu, Rong‐Rong, Du, Da‐Ming
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 23.12.2024; Wiley Subscription Services, Inc
• Subjects: 1,3-dipolar cycloaddition; Chemical synthesis; Chemistry; Chemistry, Organic; Controllability; Cycloaddition; Imines; Isatin ketimines; Isoxazolones; Oxindoles; Physical Sciences; Regioselectivity; Science & Technology; Spiroheterocycles; Stereoselectivity; Isatin ketimines; Oxindoles; Spiroheterocycles; INHIBITORS; Isoxazolones; 3+2 CYCLOADDITION; TRANSFORMATIONS; 1,3-dipolar cycloaddition; N-2,2,2-TRIFLUOROETHYLISATIN KETIMINES; DEAROMATIZATION

A strategic approach to incorporate CF3 group into oxindoles, pyrrolidines, and isoxazolones to construct spiro heterocyclic skeletons with quaternary carbon stereocenters was developed. Using a DMAP catalyst under mild conditions, the controllable synthesis of spiro oxindole‐pyrrolidine‐isoxazoline...