Myeloid‐Derived Suppressor Cell Membrane‐Coated Magnetic Nanoparticles for Cancer Theranostics by Inducing Macrophage Polarization and Synergizing Immunogenic Cell Death

• Published in: Advanced functional materials Vol. 28; no. 37
• Main Authors: Yu, Guang‐Tao, Rao, Lang, Wu, Hao, Yang, Lei‐Lei, Bu, Lin‐Lin, Deng, Wei‐Wei, Wu, Lei, Nan, Xiaolin, Zhang, Wen‐Feng, Zhao, Xing‐Zhong, Liu, Wei, Sun, Zhi‐Jun
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 12.09.2018
• Subjects: Anticancer properties; Apoptosis; Biocompatibility; Cancer; Cancer therapies; Cell death; Coating effects; Erythrocytes; immunogenic cell death; Iron oxides; macrophage; Macrophages; Magnetic resonance imaging; Materials science; myeloid‐derived suppressor cell; Nanoparticles; Pharmacology; photothermal therapy; Therapy; Tumors

A major challenge for traditional cancer therapy, including surgical resection, chemoradiotherapy, and immunotherapy, is how to induce tumor cell death and leverage the host immune system at the same time. Here, a myeloid‐derived suppressor cell (MDSC) membrane‐coated iron oxide magnetic nanoparticl...