Tissue, cell type, and breast cancer stage-specific expression of a TGF-β inducible early transcription factor gene

• Published in: Journal of cellular biochemistry Vol. 68; no. 2; pp. 226 - 236
• Main Authors: Subramaniam, M., Hefferan, T.E., Tau, K., Peus, D., Pittelkow, M., Jalal, S., Riggs, B.L., Roche, P., Spelsberg, T.C.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.1998
• Subjects: breast cancer stage; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cells, Cultured; Chromosome Mapping; Chromosomes, Human, Pair 8 - genetics; DNA-Binding Proteins - genetics; Early Growth Response Transcription Factors; Female; Gene Expression - drug effects; Genes, Immediate-Early - drug effects; Genes, Immediate-Early - genetics; Humans; Immunohistochemistry; Kruppel-Like Transcription Factors; Male; Microscopy, Confocal; Microscopy, Fluorescence; Neoplasm Staging; osteoblasts; Osteoblasts - chemistry; Osteoblasts - cytology; Osteoblasts - drug effects; rapid regulation; RNA, Messenger - drug effects; RNA, Messenger - genetics; RNA, Messenger - metabolism; TGF-β; Tissue Distribution; transcription factor; Transcription Factors - genetics; tumor suppressor; Zinc Fingers - genetics

This laboratory has previously identified a novel TGF‐β inducible early gene (TIEG) in human osteoblasts [Subramaniam et al. (1995): Nucleic Acids Res 23:4907–4912]. Using TIEG specific polyclonal antibody and immunoprecipitation methods in normal human fetal osteoblast cells (hFOB cells), we have n...