A Microenvironment Dual‐Responsive Nano‐Drug Equipped with PD‐L1 Blocking Peptide Triggers Immunogenic Pyroptosis for Prostate Cancer Self‐Synergistic Immunotherapy

• Published in: Advanced functional materials Vol. 33; no. 16
• Main Authors: Wang, He, Gao, Zhiyuan, Jiao, Di, Zhang, Yufan, Zhang, Jingtian, Wang, Tianjiao, Huang, Yuhua, Zheng, Donghui, Hou, Jianquan, Ding, Dan, Zhang, Weijie
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.04.2023
• Subjects: aggregation‐induced emission; Apoptosis; Cell death; Epigenetics; immune checkpoint blockades; Immune system; immunogenic pyroptosis; Immunotherapy; Materials science; Peptides; Photodynamic therapy; Prostate cancer; prostate cancers

Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint blockade (ICB) therapy is widely developed to improve the efficacy of cancer immunotherapy. However, the current ICD induced based on apoptosis, i.e., immunogenic apoptosis, is often restricted in immunogenicity owing...