Properties of small molecular drug loading and diffusion in a fluorinated PEG hydrogel studied by ¹H molecular diffusion NMR and ¹⁹F spin diffusion NMR

• Published in: Colloid and polymer science Vol. 288; no. 18; pp. 1655 - 1663
• Main Authors: Mathias, Errol V, Aponte, Julia, Kornfield, Julia A, Ba, Yong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.12.2010; Springer-Verlag; Springer
• Subjects: 1,3-Dimethyl-5-fluorouracil; 5-Fluorouracil; Applied sciences; Biological and medical sciences; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Diffusion; Diffusion coefficient; Drug delivery systems; Drugs; Dug delivery; Erosion; Exact sciences and technology; Fluoroalkyl double-ended poly(ethylene glycol); Food Science; General pharmacology; Hydrogel; Hydrogels; Medical sciences; Molecular diffusion; Nanotechnology and Microengineering; NMR; Nuclear magnetic resonance; Organic polymers; Original Contribution; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physical Chemistry; Physicochemistry of polymers; Polymer Sciences; Properties and characterization; Soft and Granular Matter; Solution and gel properties; Spin diffusion; 1,3-Dimethyl-5-fluorouracil; NMR; 5-Fluorouracil; Molecular diffusion; Spin diffusion; Fluoroalkyl double-ended poly(ethylene glycol); Hydrogel; Dug delivery; Antineoplastic agent; 1,3-Dimethyl-5-fluorouracil Dug delivery; Transport properties; End group; Control release polymer; Fluorine containing polymer; Physical gel; Drug carrier; Experimental study; Modeling; Molecule scattering; Ethylene oxide polymer; Hydrophobic group; Fluorouracil; Amphiphilic polymer

Rf-PEG (fluoroalkyl double-ended poly(ethylene glycol)) hydrogel is potentially useful as a drug delivery depot due to its advanced properties of sol-gel two-phase coexistence and low surface erosion. In this study, ¹H molecular diffusion nuclear magnetic resonance (NMR) and ¹⁹F spin diffusion NMR w...