Multifunctional Polymeric Nanoneedles with “Full‐Spectrum Intrinsic Internal Standard” for Precise SERS Biosensing

• Published in: Advanced functional materials Vol. 35; no. 10
• Main Authors: Wang, Li, Li, Chonghui, Cao, Chongfeng, Lei, Fengcai, Zhao, Xiaofei, Li, Zhen, Zhang, Chao, Jiao, Yang, Yu, Jing
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.03.2025
• Subjects: Algorithms; biosensing; flexible SERS substrate; Gold; internal standard; Machine learning; polymeric micro and nanoneedles; Polyvinylidene fluorides; precise quantification; Silver; Vinylidene fluoride

Polymeric micro and nanoneedles have an exceptionally flexible bio‐SERS structure. However, during detection, Raman signals from the polymer often overlap with those from the target molecules, which is unavoidable and severely compromises the accuracy of the results. To address this issue, this stud...