Synergetic Chemo‐Piezodynamic Therapy of Osteosarcoma Enabled by Defect‐Driven Lead‐Free Piezoelectrics

• Published in: Advanced functional materials Vol. 32; no. 44
• Main Authors: Wang, Shidong, Chen, Chenglong, Wang, Juan, Li, Chen‐Bo‐Wen, Zhou, Jinling, Liu, Yi‐Xuan, Jiang, Yu‐Qi, Zhu, Lifeng, Li, Chao, Gong, Wen, Guo, Wei, Tang, Xiaodong, Yao, Fang‐Zhou, Wang, Ke
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.10.2022
• Subjects: (K,Na)NbO 3; Apoptosis; Biocompatibility; Bone cancer; Catalysis; chemodynamic therapies; Defects; Evaluation; Free radicals; lead‐free piezoelectrics; Materials science; Nanocrystals; osteosarcoma; Oxygen; piezodynamic therapies; Piezoelectricity; Therapy; Toxicity; Tumors; Ultrasonic vibration; Xenotransplantation

Osteosarcoma (OS) is a lethal malignancy of the bone, jeopardizing the life of an enormous population worldwide. There are grand ongoing challenges to improve overall patient survival. Herein, a synergetic chemo‐piezodynamic therapy by defect‐engineered lead‐free piezoelectric (K,Na)NbO3 (KNN) is re...