Pd‐Catalyzed MIA‐Directed Acetoxylation of Benzylamines and Computational Study

• Published in: European journal of organic chemistry Vol. 2022; no. 37
• Main Authors: Meng, Yue‐Ning, Zhao, Shi‐Chen, Liu, Peng‐Yu, Hu, Dianwen, Wang, Shuai, He, Yu‐Peng, Yu, Fang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.10.2022; Wiley Subscription Services, Inc
• Subjects: Acetoxylation; Benzylamines; Chemistry; Chemistry, Organic; C−H functionalization; Methoxyiminoacyl; Palladium; Pd-catalyzed; Phenylalanine; Physical Sciences; Science & Technology; Substrates; MECHANISM; Acetoxylation; Pd-catalyzed; ARYLATION; BONDS; Benzylamines; C(SP)-H; C-H functionalization; Methoxyiminoacyl

The direct acetoxylation of substituted benzylamines has been accomplished through methoxyiminoacyl (MIA)‐mediated Pd‐catalyzed C−H functionalization. A diverse array of phenylalanine substrates is amenable to this protocol, providing acetoxylation benzylamine derivatives with good to high efficienc...