Cardiovascular Risk in Patients with Subclinical Hypothyroidism

Subclinical hypothyroidism (SCH) has been associated with increased cardiovascular mortality due to adverse effects mainly on lipids and blood pressure (BP). There is evidence that SCH, especially in patients with thyroid-stimulating hormone (TSH) >10mU/l, may increase cardiovascular risk. Some u...

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Published inEuropean endocrinology Vol. 10; no. 2; pp. 157 - 160
Main Authors H Duntas, Leonidas, Chiovato, Luca
Format Journal Article
LanguageEnglish
Published England Touch Medical Media 01.08.2014
Subjects
Cardiovascular Risk
Thyroid Disorders
metabolic syndrome
thyroid-stimulating hormone
blood pressure
lipids
cardiovascular risk
Subclinical hypothyroidism
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Abstract Subclinical hypothyroidism (SCH) has been associated with increased cardiovascular mortality due to adverse effects mainly on lipids and blood pressure (BP). There is evidence that SCH, especially in patients with thyroid-stimulating hormone (TSH) >10mU/l, may increase cardiovascular risk. Some uncertainty exists regarding the association of SCH with BP; however, that the coexistence of SCH with BP and hypercholesterolaemia has a negative cardiovascular impact is beyond doubt. Insulin resistance, by modulating various risk factors including coagulation, may potentially increase cardiovascular risk. Periodic health examinations including screening has been advised in patients >35 years of age, while treatment with thyroxine should be tailored to each patient.
AbstractList Subclinical hypothyroidism (SCH) has been associated with increased cardiovascular mortality due to adverse effects mainly on lipids and blood pressure (BP). There is evidence that SCH, especially in patients with thyroid-stimulating hormone (TSH) >10mU/l, may increase cardiovascular risk. Some uncertainty exists regarding the association of SCH with BP; however, that the coexistence of SCH with BP and hypercholesterolaemia has a negative cardiovascular impact is beyond doubt. Insulin resistance, by modulating various risk factors including coagulation, may potentially increase cardiovascular risk. Periodic health examinations including screening has been advised in patients >35 years of age, while treatment with thyroxine should be tailored to each patient.
Author H Duntas, Leonidas
Chiovato, Luca
AuthorAffiliation 1 Professor, Unit of Endocrinology, Metabolism and Diabetes, Evgenidion Hospital, University of Athens, Greece
2 Professor, Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri Istituto di Ricovero e Cura a Carattere Scientifico, University of Pavia, Italy
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Keywords metabolic syndrome
thyroid-stimulating hormone
blood pressure
lipids
cardiovascular risk
Subclinical hypothyroidism
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Disclosure: Leonidas H Duntas and Luca Chiovato have no conflicts of interest to declare. No funding was received for the publication of this article.
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