A Novel Ce─Mn Heterojunction‐Based Multi‐Enzymatic Nanozyme with Cancer‐Specific Enzymatic Activity and Photothermal Capacity for Efficient Tumor Combination Therapy

• Published in: Advanced functional materials Vol. 35; no. 6
• Main Authors: Qiao, Qianqian, Liu, Zerui, Hu, Fei, Xu, Ziqiang, Kuang, Ying, Li, Cao
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.02.2025
• Subjects: Ablation; Acidic oxides; Cancer; cascade enzyme system; Catalase; Catalytic activity; catalytic medicine; Cerium oxides; Chemical synthesis; combination therapy; Density functional theory; Enzymes; Glucose oxidase; Glutathione; heterojunction; Heterojunctions; Hydrogen peroxide; multi‐enzymatic nanozyme; Nanoclusters; Oxidation; Peroxidase; Polyethylene glycol; Potassium permanganate; Sulfuric acid; Therapy; Tumors

Catalytic medicine, using enzymes or nanozymes, is an emerging method for cancer treatment. However, its applicability is limited by the low catalytic activity in the tumor microenvironment (TME). In this work, a versatile and synthesis‐friendly nanozyme, CeO2Mn1.08Ox nanoclusters, is prepared. This...