Low‐Dose Cu Ions Assisted by Mild Thermal Stimulus Inducing Bacterial Cuproptosis‐Like Death for Antibiosis and Biointegration

• Published in: Advanced functional materials Vol. 34; no. 1
• Main Authors: Xue, Yang, Zhang, Lan, Zhou, Jianhong, Chen, Jun, Ma, Yuwei, Han, Yong
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.01.2024
• Subjects: antibiosis; biointegration; Copper; cuproptosis; Cu‐doped hydroxyapatite; Destabilization; Glutathione; Hydroxyapatite; Irradiation; Nanorods; Near infrared radiation; Peroxides; photothermal; Polyether ether ketones; Proteins; Staphylococcus infections

Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance to multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle of cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether cuprop...