Bicyclo[1.1.1]pentane‐Derived Building Blocks for Click Chemistry

• Published in: European journal of organic chemistry Vol. 2017; no. 43; pp. 6450 - 6456
• Main Authors: Kokhan, Serhii O., Valter, Yevheniia B., Tymtsunik, Andriy V., Komarov, Igor V., Grygorenko, Oleksandr O.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 24.11.2017; Wiley Subscription Services, Inc
• Subjects: Alkynes; Azides; Cage compounds; Carboxylic acids; Chemical synthesis; Chemistry; Chemistry, Organic; Click chemistry; Combinatorial analysis; Homology; Imidazole; Nitrogen heterocycles; Pentanes; Physical Sciences; Propellane; Science & Technology; Substrates; Cage compounds; CUBANES; EXPEDIENT SYNTHESIS; BRIDGEHEAD; TINKERTOY CONSTRUCTION SET; RING-SYSTEM; AZIDE; RECEPTOR ANTAGONIST; MEDICINAL CHEMISTRY; Azides; Propellane; BIOORTHOGONAL REACTIONS; Nitrogen heterocycles; BIOCONJUGATION; Click chemistry; Alkynes

Syntheses of bicyclo[1.1.1]pentane‐derived azides and terminal alkynes – interesting substrates for click reactions – are described. With a few exceptions, these compounds were prepared in two or three steps starting from common synthetic intermediates – the corresponding carboxylic acids. The key s...