Guaiane‐type Sesquiterpenoid Dimers from Artemisia zhongdianensis and Antihepatoma Carcinoma Activity via the p38MAPK Pathway

• Published in: Chinese journal of chemistry Vol. 41; no. 19; pp. 2453 - 2468
• Main Authors: Dong, Wei, Ma, Wen‐Jing, Ma, Yun‐Bao, Li, Feng‐Jiao, Li, Tian‐Ze, Wang, Yong‐Cui, He, Xiao‐Feng, Geng, Chang‐An, Zhang, Xue‐Mei, Chen, Ji‐Jun
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.10.2023; Wiley; Wiley Subscription Services, Inc
• Subjects: Absolute configuration; Adducts; Antihepatoma activity; Apoptosis; Artemisia zhongdianensis; Artemzhongdianolides B1—B17; Bioassays; Cancer; Cell cycle; Cell migration; Chemistry; Chemistry, Multidisciplinary; Cytotoxicity; Dimers; Guaiane‐type sesquiterpenoid dimers; Hepatoma; Machine learning; NMR; NMR spectroscopy; Nuclear magnetic resonance; p38MAPK pathway; Physical Sciences; Science & Technology; Signal transduction; Two dimensional analysis; X‐ray diffraction; ARREST; CELLS; Artemzhongdianolides B1-B17; Antihepatoma activity; Artemisia zhongdianensis; JNK; X-ray diffraction; NMR spectroscopy; Guaiane-type sesquiterpenoid dimers; p38MAPK pathway; Cancer

Comprehensive Summary 17 new guaiane‐type sesquiterpenoid dimers (GSDs), artemzhongdianolides B1—B17 (1—17), were isolated from Artemisia zhongdianensis under the guidance of bioassay, and elucidated by spectral analyses (HRESIMS, 1D and 2D NMR, IR, ECD). The absolute configuration of compounds 1, 3...