Self‐Mineralized Photothermal Bacteria Hybridizing with Mitochondria‐Targeted Metal–Organic Frameworks for Augmenting Photothermal Tumor Therapy
A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PT...
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| Published in | Advanced functional materials Vol. 30; no. 14 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hoboken
Wiley Subscription Services, Inc
01.04.2020
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| Abstract | A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen (1O2) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT.
A bacteria‐based photothermal therapeutic platform comprising PTB@ZIF‐90/MB is developed, which reveals great potential to augment photothermal therapy efficacy by tackling the challenges of tumor targeting and heat resistance. |
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| AbstractList | A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen (1O2) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT.
A bacteria‐based photothermal therapeutic platform comprising PTB@ZIF‐90/MB is developed, which reveals great potential to augment photothermal therapy efficacy by tackling the challenges of tumor targeting and heat resistance. A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen (1O2) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT. A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 ( S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen ( 1 O 2 ) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT. |
| Author | Wang, Jia‐Wei Peng, Si‐Yuan Liu, Xin‐Hua Liu, Chuan‐Jun Zhang, Cheng Zhang, Xian‐Zheng Fan, Jin‐Xuan Wang, Xia‐Nan Chen, Qi‐Wen |
| Author_xml | – sequence: 1 givenname: Qi‐Wen surname: Chen fullname: Chen, Qi‐Wen organization: Wuhan University – sequence: 2 givenname: Xin‐Hua surname: Liu fullname: Liu, Xin‐Hua organization: Wuhan University – sequence: 3 givenname: Jin‐Xuan surname: Fan fullname: Fan, Jin‐Xuan organization: Wuhan University – sequence: 4 givenname: Si‐Yuan surname: Peng fullname: Peng, Si‐Yuan organization: Wuhan University – sequence: 5 givenname: Jia‐Wei surname: Wang fullname: Wang, Jia‐Wei organization: Wuhan University – sequence: 6 givenname: Xia‐Nan surname: Wang fullname: Wang, Xia‐Nan organization: Wuhan University – sequence: 7 givenname: Cheng surname: Zhang fullname: Zhang, Cheng organization: Wuhan University – sequence: 8 givenname: Chuan‐Jun surname: Liu fullname: Liu, Chuan‐Jun organization: Wuhan University – sequence: 9 givenname: Xian‐Zheng orcidid: 0000-0001-6242-6005 surname: Zhang fullname: Zhang, Xian‐Zheng email: xz-zhang@whu.edu.cn organization: Wuhan University |
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| Cites_doi | 10.1038/s41467-018-03233-9 10.1039/C1CS15166E 10.1016/j.addr.2016.09.007 10.1002/anie.201803766 10.1021/jacs.8b11996 10.1021/acsnano.8b03241 10.1111/j.1462-2920.2005.00696.x 10.1021/nn5011304 10.1126/sciadv.aav1848 10.1021/la9027755 10.1038/nnano.2016.137 10.1039/C8TA01318G 10.1002/adma.201900401 10.1038/s41568-018-0070-z 10.1021/jacs.7b01229 10.1002/adfm.201808222 10.1021/ja805222x 10.1002/adma.201808278 10.1111/1348-0421.12134 10.1021/acs.nanolett.7b05323 10.1039/b802258p 10.1038/nrc3672 10.1038/s41551-019-0423-2 10.1038/nrd.2018.174 10.1016/j.scib.2017.02.012 10.1038/s41565-019-0373-6 10.1002/adfm.201904093 10.1021/acs.inorgchem.8b01316 10.1002/anie.201701964 10.1038/nrc2934 10.1038/nrmicro.2017.44 10.3109/1040841X.2013.776511 10.1039/C5CS00133A 10.1021/acsnano.8b02235 10.1021/acs.nanolett.6b00262 |
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| References | 2017; 62 2010; 10 2019; 3 2019; 5 2019; 31 2019; 14 2016; 106 2014; 40 2019; 141 2016; 16 2017; 139 2016; 11 2011; 2011 2018; 6 2018; 9 2018; 18 2018; 17 2010; 26 2017; 15 2015; 44 2017; 56 2014; 14 2005; 7 2014; 58 2019; 29 2018; 12 2014; 8 2009; 38 2008; 130 2012; 41 2018; 57 e_1_2_7_6_1 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_1_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 Li X. (e_1_2_7_14_1) 2011; 2011 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_20_1 e_1_2_7_36_1 |
| References_xml | – volume: 18 start-page: 727 year: 2018 publication-title: Nat. Rev. Cancer – volume: 16 start-page: 3493 year: 2016 publication-title: Nano Lett. – volume: 6 year: 2018 publication-title: J. Mater. Chem. A – volume: 141 start-page: 3782 year: 2019 publication-title: J. Am. Chem. Soc. – volume: 57 start-page: 7836 year: 2018 publication-title: Angew. Chem., Int. Ed. – volume: 40 start-page: 225 year: 2014 publication-title: Crit. Rev. Microbiol. – volume: 12 start-page: 6351 year: 2018 publication-title: ACS Nano – volume: 58 start-page: 172 year: 2014 publication-title: Microbiol. Immunol. – volume: 31 year: 2019 publication-title: Adv. Mater. – volume: 9 start-page: 1680 year: 2018 publication-title: Nat. Commun. – volume: 56 start-page: 6519 year: 2017 publication-title: Angew. Chem., Int. Ed. – volume: 18 start-page: 2373 year: 2018 publication-title: Nano Lett. – volume: 14 start-page: 379 year: 2019 publication-title: Nat. Nanotechnol. – volume: 7 start-page: 314 year: 2005 publication-title: Environm. Microbiol. – volume: 11 start-page: 941 year: 2016 publication-title: Nat. Nanotech. – volume: 26 start-page: 2505 year: 2010 publication-title: Langmuir – volume: 12 start-page: 5995 year: 2018 publication-title: ACS Nano – volume: 38 start-page: 1315 year: 2009 publication-title: Chem. Soc. Rev. – volume: 29 year: 2019 publication-title: Adv. Funct. Mater. – volume: 14 start-page: 199 year: 2014 publication-title: Nat. Rev. Cancer – volume: 139 start-page: 5877 year: 2017 publication-title: J. Am. Chem. Soc. – volume: 57 year: 2018 publication-title: Inorg. Chem. – volume: 44 start-page: 6330 year: 2015 publication-title: Chem. Soc. Rev. – volume: 10 start-page: 784 year: 2010 publication-title: Nat. Rev. Cancer – volume: 3 start-page: 717 year: 2019 publication-title: Nat. Biomed. Eng. – volume: 8 start-page: 5049 year: 2014 publication-title: ACS Nano – volume: 15 start-page: 465 year: 2017 publication-title: Nat. Rev. Microbiol. – volume: 106 start-page: 27 year: 2016 publication-title: Adv. Drug Delivery Rev. – volume: 5 year: 2019 publication-title: Sci. Adv. – volume: 130 year: 2008 publication-title: J. Am. Chem. Soc. – volume: 17 start-page: 865 year: 2018 publication-title: Nat. Rev. Drug Discovery – volume: 2011 start-page: 16 year: 2011 publication-title: J. Nanomater. – volume: 41 start-page: 2256 year: 2012 publication-title: Chem. Soc. Rev. – volume: 62 start-page: 579 year: 2017 publication-title: Sci. Bull. – ident: e_1_2_7_4_1 doi: 10.1038/s41467-018-03233-9 – ident: e_1_2_7_18_1 doi: 10.1039/C1CS15166E – ident: e_1_2_7_1_1 doi: 10.1016/j.addr.2016.09.007 – ident: e_1_2_7_27_1 doi: 10.1002/anie.201803766 – ident: e_1_2_7_25_1 doi: 10.1021/jacs.8b11996 – ident: e_1_2_7_8_1 doi: 10.1021/acsnano.8b03241 – ident: e_1_2_7_22_1 doi: 10.1111/j.1462-2920.2005.00696.x – ident: e_1_2_7_33_1 doi: 10.1021/nn5011304 – ident: e_1_2_7_19_1 doi: 10.1126/sciadv.aav1848 – ident: e_1_2_7_24_1 doi: 10.1021/la9027755 – ident: e_1_2_7_5_1 doi: 10.1038/nnano.2016.137 – ident: e_1_2_7_17_1 doi: 10.1039/C8TA01318G – ident: e_1_2_7_30_1 doi: 10.1002/adma.201900401 – ident: e_1_2_7_7_1 doi: 10.1038/s41568-018-0070-z – ident: e_1_2_7_21_1 doi: 10.1021/jacs.7b01229 – ident: e_1_2_7_34_1 doi: 10.1002/adfm.201808222 – ident: e_1_2_7_32_1 doi: 10.1021/ja805222x – ident: e_1_2_7_12_1 doi: 10.1002/adma.201808278 – ident: e_1_2_7_36_1 doi: 10.1111/1348-0421.12134 – volume: 2011 start-page: 16 year: 2011 ident: e_1_2_7_14_1 publication-title: J. Nanomater. – ident: e_1_2_7_16_1 doi: 10.1021/acs.nanolett.7b05323 – ident: e_1_2_7_31_1 doi: 10.1039/b802258p – ident: e_1_2_7_13_1 doi: 10.1038/nrc3672 – ident: e_1_2_7_11_1 doi: 10.1038/s41551-019-0423-2 – ident: e_1_2_7_20_1 doi: 10.1038/nrd.2018.174 – ident: e_1_2_7_23_1 doi: 10.1016/j.scib.2017.02.012 – ident: e_1_2_7_28_1 doi: 10.1038/s41565-019-0373-6 – ident: e_1_2_7_35_1 doi: 10.1002/adfm.201904093 – ident: e_1_2_7_26_1 doi: 10.1021/acs.inorgchem.8b01316 – ident: e_1_2_7_29_1 doi: 10.1002/anie.201701964 – ident: e_1_2_7_3_1 doi: 10.1038/nrc2934 – ident: e_1_2_7_6_1 doi: 10.1038/nrmicro.2017.44 – ident: e_1_2_7_2_1 doi: 10.3109/1040841X.2013.776511 – ident: e_1_2_7_15_1 doi: 10.1039/C5CS00133A – ident: e_1_2_7_10_1 doi: 10.1021/acsnano.8b02235 – ident: e_1_2_7_9_1 doi: 10.1021/acs.nanolett.6b00262 |
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| Snippet | A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1... A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (... |
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| SubjectTerms | Adenosine triphosphate Bacteria cancer therapy Encapsulation Heat shock proteins Heat tolerance heat‐shock protein Imidazole Materials science Metal-organic frameworks Methylene blue Mitochondria Nanoparticles Palladium photothermal therapy Singlet oxygen Tumors |
| Title | Self‐Mineralized Photothermal Bacteria Hybridizing with Mitochondria‐Targeted Metal–Organic Frameworks for Augmenting Photothermal Tumor Therapy |
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