Synthesis of C2‐Functionalized Pyrimidine Derivatives by Using Arynes and Dithiopyrimidines

• Published in: European journal of organic chemistry Vol. 26; no. 29
• Main Authors: Yang, Chun‐Hong, Wang, Wen‐Peng, Li, Ming, Gao, Fan, Ma, Wen, Chen, Dong‐Ping, Wang, Xi‐Cun, Quan, Zheng‐Jun
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 01.08.2023; Wiley Subscription Services, Inc
• Subjects: aryl thiopyrimidine; benzyne; Cesium fluorides; Chemistry; Chemistry, Organic; Density functional theory; DFT calculations; dithiopyrimidines; Heterocyclic compounds; Physical Sciences; Science & Technology; Substrates; Synthesis; synthetic methods; aryl thiopyrimidine; benzyne; REAGENTS; dithiopyrimidines; EFFICIENT SYNTHESIS; IMIDAZOLES; DFT calculations; DISULFIDES; POTENT; CHEMISTRY; INHIBITORS; N-ARYLATION; PALLADIUM-CATALYZED ANNULATION; synthetic methods; ACCESS

C2‐functionalized pyrimidine derivative is a family of important nitrogen heterocyclic compounds due to their unique structure and multiple reaction sites. In this work, a novel method for the synthesis of C2‐functionalized pyrimidine derivatives through phenylalkynes and pyrimidine disulfides under...