Dual‐Targeting Photosensitizer‐Peptide Amphiphile Conjugate for Enzyme‐Triggered Drug Delivery and Synergistic Chemo‐Photodynamic Tumor Therapy

• Published in: Advanced materials interfaces Vol. 7; no. 19
• Main Authors: Cheng, Yin‐Jia, Qin, Si‐Yong, Liu, Wen‐Long, Ma, Yi‐Han, Chen, Xiao‐Sui, Zhang, Ai‐Qing, Zhang, Xian‐Zheng
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.10.2020
• Subjects: Aqueous solutions; biomaterials; Cathepsin B; Conjugates; Doxorubicin; Drug delivery systems; drug release; enzyme‐responsive; Light irradiation; micelles; Mitochondria; Peptides; Photodynamic therapy; Toxicity; tumor therapy; Tumors

Chemo‐photodynamic therapy is an attractive strategy in tumor treatment. However, the combination of chemotherapeutic drug and photosensitizer in nanocarriers always elevates the risk of composition uncertainty. Here, a dual‐targeting photosensitizer‐peptide amphiphile conjugate (PpIX‐GGGK(TPP)GG‐GF...