Solid‐Phase Synthesis of Peptidols via Reductive Cleavage Through a Benzotriazole Linker

• Published in: Advanced synthesis & catalysis Vol. 366; no. 11; pp. 2534 - 2543
• Main Authors: Chen, Szu‐Hsuan, Chuang, Hui‐Ying, Rajavel, Chitra, Kai Lin, Yi, Chang, Shu‐Han, Tsai, Pei‐Chen, Chen, Hui‐Ting, Sun, Chung‐Ming, Selvaraj, Anand, Kao, Chai‐Lin
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 10.06.2024; Wiley Subscription Services, Inc
• Subjects: Amino acids; Aspartic acid; Benzotriazole; Carboxylic acids; Chemistry; Chemistry, Applied; Chemistry, Organic; Cleavage; Esters; on-bead reduction; Peptides; Peptidol; Physical Sciences; Reductive cleavage; Residues; Science & Technology; Solid phase synthesis; Solid-phase peptide synthesis; ALCOHOLS; ACID; on-bead reduction; Peptidol; Reductive cleavage; THIOESTER; Solid-phase peptide synthesis; PRECURSORS

Peptidols were prepared through the reductive cleavage of benzotriazole intermediates obtained from the on‐bead activation of 3,4‐diaminobenzoyl linkers. Remarkably, this method used commercially available amino acid residues and resins without further modification. Pure peptidols were collected wit...