Metal‐Free and NBS‐Mediated Direct Thiol‐Disulfide Exchange Reaction to Access Unsymmetrical Disulfides

• Published in: European journal of organic chemistry Vol. 26; no. 30
• Main Authors: Yang, Ke, Hu, Qingyue, Li, Qin, Liu, Junxiang, Li, Zheng‐Yi, Li, Bijin, Sun, Xiaoqiang
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 07.08.2023; Wiley Subscription Services, Inc
• Subjects: Amino acids; Chemistry; Chemistry, Organic; Disulfides; Functional groups; NBS; Physical Sciences; Room temperature; Science & Technology; Substrates; synthetic methods; thiols; disulfides; DESIGN; EFFICIENT SYNTHESIS; GENERATION; thiols; C-H FUNCTIONALIZATION; MICROWAVE-ASSISTED SYNTHESIS; synthetic methods; NBS; DISULFANES; FREE OXIDATION

A metal‐free and N‐Bromosuccinimide (NBS)‐mediated direct thiol‐disulfide exchange reaction at room temperature is developed. A variety of unsymmetrical disulfides have been prepared with good to excellent yields. Efficient late‐stage modification of amino acids and drugs demonstrates the utility of...