One‐Pot Synthesis of Indolizines Using TBHP as the Methylene Source Under Metal‐Free Condition

• Published in: European journal of organic chemistry Vol. 2020; no. 2; pp. 262 - 266
• Main Authors: Zhang, Qianwei, Ablajan, Keyume, Wang, Bin, Ma, Huifang, Guo, Zhongqi
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 16.01.2020; Wiley Subscription Services, Inc
• Subjects: Aromatic compounds; Butyl hydroperoxide; Cascade chemical reactions; Chemical synthesis; Chemistry; Chemistry, Organic; Cycloaddition; Heterocycles; Ketones; Metal‐free; Methylene; Methylene source; Multicomponent reactions; Oxidizing agents; Physical Sciences; Science & Technology; Heterocycles; Metal-free; H BOND; CATALYZED ANNULATION; DIAZO-COMPOUNDS; ALKENES; Cycloaddition; CINNAMIC-ACIDS; Methylene source; Multicomponent reactions; SUBSTITUTED INDOLIZINES; PYRIDINIUM YLIDES; C-C BOND; ALKYLATION-PEROXIDATION

An I2/tert‐butyl hydroperoxide (TBHP)‐mediated [2+1+1+1] cycloadditions/oxidative aromatization reactions for the synthesis of indolizines using the one‐pot cascade process have been developed. A variety of aryl methyl ketones react with pyridine/isoquinoline and TBHP in the transition‐metal‐free re...