Synthesis of Polycyclic Quinazolinones through C(sp3)−H Functionalization of Inert Alkanes or Visible‐Light‐Promoted Oxidation Decarboxylation of N‐Hydroxyphthalimide Esters

• Published in: European journal of organic chemistry Vol. 2022; no. 35
• Main Authors: Zhang, Wei‐Kang, Li, Jiao‐Zhe, Zhang, Can‐Can, Zhang, Jian, Zheng, Yan‐Nan, Hu, Yufang, Li, Ting, Wei, Wen‐Ting
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 20.09.2022; Wiley Subscription Services, Inc
• Subjects: Alkanes; Chemistry; Chemistry, Organic; C−H functionalization; Decarboxylation; Esters; Green synthesis; Oxidation; Physical Sciences; Quinazolinones; Radical reactions; Science & Technology; Substrates; Visible light; ACID; Alkanes; Visible light; CATALYST; C-H functionalization; TRIPHENYLPHOSPHINE; LUOTONIN; CYANAMIDE ALKENES; Radical reactions; 1,6-DIENES; RUTAECARPINE; Green synthesis; METAL-COMPLEXES; CYCLIZATION; WATER

Two novel C(sp3)−H functionalization of inert alkanes and visible‐light promoted oxidation decarboxylation of N‐hydroxyphthalimide (NHP) esters to access polycyclic quinazolinones have been described. These methods do not involve metal catalysts and are carried out in water or water/DMSO media. The...