Highly Efficient Two‐Photon Photodynamic Therapy Using Light‐Sheet Excitation

• Published in: Laser & photonics reviews Vol. 18; no. 11
• Main Authors: Pang, Wen, Wang, Chen, Wu, Wenbo, Wei, Xunbin, Gu, Bobo
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 01.11.2024
• Subjects: aggregation induced emission; Excitation; Light; light‐sheet; Photodynamic therapy; Photons; Tumors; two‐photon photodynamic therapy
• ISSN: 1863-8880; 1863-8899
• DOI: 10.1002/lpor.202400753

Two‐photon photodynamic therapy (TP‐PDT), which utilizes near‐infrared light to excite photosensitizer via two‐photon excitation (TPE), is a promising modality in the treatment of deeply seated tumors or thick tumors. However, the TPE domain is much smaller than the tumor volume, significantly limit...