pH Switchable Nanoplatform for In Vivo Persistent Luminescence Imaging and Precise Photothermal Therapy of Bacterial Infection

• Published in: Advanced functional materials Vol. 30; no. 14
• Main Authors: Yan, Li‐Xia, Chen, Li‐Jian, Zhao, Xu, Yan, Xiu‐Ping
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.04.2020
• Subjects: Bacteria; bacterial infection; Bacterial infections; Biocompatibility; charge conversion; Chitosan; Drug resistance; Electrostatic bonding; Imaging; imaging‐guided photothermal therapy; Infections; Infrared radiation; Light irradiation; Luminescence; Materials science; Microorganisms; Nanoparticles; persistent luminescence nanoparticles; Photothermal conversion; Polyanilines; Surface charge; Toxicity

Photothermal therapy (PTT) is one of the most promising approaches to combat multidrug‐resistant bacteria with less potential to induce resistance and systemic toxicity. However, uncontrollable distribution of photothermal agents leads to lethal temperatures for normal cells, and failure to offer ti...