Staggered Stacking Covalent Organic Frameworks for Boosting Cancer Immunotherapy

• Published in: Advanced functional materials Vol. 32; no. 29
• Main Authors: Zhang, Liang, Xiao, Yao, Yang, Qi‐Chao, Yang, Lei‐Lei, Wan, Shu‐Cheng, Wang, Shuo, Zhang, Lu, Deng, Hexiang, Sun, Zhi‐Jun
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.07.2022
• Subjects: Antioxidants; Cancer; Catalase; Cell death; covalent organic frameworks; Glutathione; Hydrogen peroxide; Hypoxia; immunogenic cell deaths; Immunotherapy; Interlayers; Materials science; Oxygen; Peroxidase; Photochemical reactions; phototherapy; Porphyrins; ROS amplifiers; Scavenging; Stacking; staggered stacking modes

The synergistic efficacy of phototherapy and cancer immunotherapy is severely restricted by both the inherent photobleaching and aggregation‐caused quench (ACQ) defects of photosensitizers and the intrinsic antioxidant tumor microenvironment (TME), such as hypoxia and overexpressed glutathione (GSH)...