Asymmetric Two‐Component Alkenyl Catellani Reaction for the Construction of C—N Axial Chirality

• Published in: Chinese journal of chemistry Vol. 42; no. 7; pp. 699 - 704
• Main Authors: Wu, Chenggui, Liu, Ze‐Shui, Shang, Yong, Liu, Chang, Deng, Shuang, Cheng, Hong‐Gang, Cong, Hengjiang, Jiao, Yinchun, Zhou, Qianghui
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY‐VCH Verlag GmbH & Co. KGaA 01.04.2024; Wiley; Wiley Subscription Services, Inc
• Subjects: Alkenyl Catellani reaction; Asymmetric catalysis; Asymmetry; Atropisomerism; Axial‐to‐axial chirality transfer; Bromides; Catalysis; Chemistry; Chemistry, Multidisciplinary; Chirality; Coumarin; Heterocycles; Palladium; Physical Sciences; Quinoline; Quinolones; Science & Technology; Substrates; Uracil; AROMATIC FUNCTIONALIZATION; Heterocycles; PALLADIUM; ENANTIOSELECTIVE SYNTHESIS; ANNULATION; Atropisomerism; STEREOCHEMICAL RELAY; Asymmetric catalysis; PD/NORBORNENE; Axial-to-axial chirality transfer; H FUNCTIONALIZATION; NORBORNENE; Alkenyl Catellani reaction; REGIOSELECTIVE SYNTHESIS; ARYL IODIDES

Comprehensive Summary Herein, we report an asymmetric two‐component alkenyl Catellani reaction for the construction of C—N axial chirality through a palladium/chiral norbornene cooperative catalysis and an axial‐to‐axial chirality transfer process. Various partially aromatic iodinated 2‐pyridones, q...