Distinct Dynamic and Conformational Features of Human STING in Response to 2′3′‐cGAMP and c‐di‐GMP

• Published in: Chembiochem : a European journal of chemical biology Vol. 20; no. 14; pp. 1838 - 1847
• Main Authors: Guo, Jingjing, Wang, Jie, Fan, Jingrong, Zhang, Yan, Dong, Wenpei, Chen, Chang‐Po
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 15.07.2019
• Subjects: Activation; Binding; cyclic dinucleotides; Cytokines; Drug development; Human behavior; Inflammation; Interferon; ligand effects; Molecular dynamics; Principles; proteins; Stimulators

The human stimulator of interferon genes protein (hSTING) can bind cyclic dinucleotides (CDNs) to activate the production of type I interferons and inflammatory cytokines. These CDNs can be either bacterial secondary messengers, 3′3′‐CDNs, or endogenous 2′3′‐cGAMP. cGAMP, with a unique 2′–5′ bond, i...