Methylthiolation for Electron‐Rich Heteroarenes with DMSO‐TsCl

• Published in: European journal of organic chemistry Vol. 2021; no. 9; pp. 1446 - 1451
• Main Authors: Zhang, Lei‐Yang, Wu, Yue‐Hua, Wang, Nai‐Xing, Gao, Xue‐Wang, Yan, Zhan, Xu, Bao‐Cai, Liu, Ning, Wang, Bo‐Zhou, Xing, Yalan
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 05.03.2021; Wiley Subscription Services, Inc
• Subjects: Chemistry; Chemistry, Organic; C−S bond coupling; Furans; Heterocycles; Methylthiolation; Physical Sciences; Pyrroles; Regioselectivity; Science & Technology; Synthetic methods; Thiophenes; Heterocycles; Synthetic methods; Methylthiolation; C− S bond coupling

DMSO‐TsCl has been developed for direct methylthiolation of various electron‐rich heteroarenes (more than 40 examples) with high regioselectivity in moderate to excellent yields (up to 96 %). Especially, pyrroles, furans, and thiophenes can be efficiently mono‐methylthiolated. This practical method...