Magnetic‐Activated Nanosystem with Liver‐Specific CRISPR Nonviral Vector to Achieve Spatiotemporal Liver Genome Editing as Hepatitis B Therapeutics

• Published in: Advanced functional materials Vol. 33; no. 7
• Main Authors: Zhuo, Chenya, Kong, Huiming, Yi, Ke, Chi, Chun‐Wei, Zhang, Jiabing, Chen, Ran, Wang, Haixia, Wu, Caixia, Lao, Yeh‐Hsing, Tao, Yu, Li, Mingqiang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.02.2023
• Subjects: CRISPR; CRISPR/Cas9; Editing; gene editing; Genetic modification; Genomes; Hepatitis B; hepatitis B virus (HBV); Interferon; Liver; liver‐specific promoters; magnetic nanosystems; Materials science; Nanoparticles; Polyethyleneimine

Chronic hepatitis B infection remains incurable due to the stable presence of various forms of hepatitis B virus (HBV) genome, especially the HBV covalently closed circular DNA (cccDNA). The emergence of clustered regularly interspaced short palindromic repeat (CRISPR) technology provides a new oppo...