Probing the Scope of the Amidine–1,2,3‐triazine Cycloaddition as a Prospective Click Ligation Method

• Published in: European journal of organic chemistry Vol. 2018; no. 37; pp. 5081 - 5085
• Main Authors: Siegl, Sebastian J., Vrabel, Milan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 09.10.2018
• Subjects: Biomolecules; Chemical reactions; Click chemistry; Cycloaddition; Diels–Alder reactions; Functional groups; Ligation; Nitrogen heterocycles; Organic chemistry

Despite recent achievements in the development of chemical reactions enabling selective modification of complex biomolecules, the demand for fast and efficient methodologies that allow the attachment of various functional groups to these systems is the subject of intense research. Here, we report on...