Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow

• Published in: Microfluidics and nanofluidics Vol. 22; no. 8; pp. 1 - 13
• Main Authors: Li, Yong-Jiang, Cao, Tun, Qin, Kai-Rong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer Nature B.V
• Subjects: Analytical Chemistry; Biochemistry; Biomedical Engineering and Bioengineering; Cells; Convection; Dye dispersion; Dynamic analysis; Engineering; Engineering Fluid Dynamics; Flow rates; Flow velocity; Frequency dependence; Frequency modulation; Low pass filters; Mathematical models; Microfluidics; Nanotechnology and Microengineering; Perturbation method; Perturbation methods; Research Paper; Time dependence; Transmission characteristics; Dynamic biochemical signals; Microfluidics; Nonlinear modulation; Low-pass filtering

A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the tra...