Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow
A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the tra...
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| Published in | Microfluidics and nanofluidics Vol. 22; no. 8; pp. 1 - 13 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.08.2018
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1613-4982 1613-4990 |
| DOI | 10.1007/s10404-018-2097-6 |
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| Abstract | A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the transmission characteristics of dynamic biochemical signals in pulsatile flows by analytically solving the convection–diffusion equation for the time-dependent Taylor–Aris dispersion with perturbation method. We prove that the transmission of dynamic biochemical signals in pulsatile flows is subject to the two correlate effects: low-pass filtering and nonlinear amplitude–frequency modulation. These two effects are systematically characterized and the influence factors are studied, including the biochemical signal frequency, the pulsatile flow frequency, the transmission distance and the average pulsatile flow rate. We concluded that the balance of multiple factors should be taken into account for better loading biochemical signals on cells cultured in the microfluidic channel. |
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| AbstractList | A controlled quantitative loading of dynamic biochemical signals on cells in vitro is essential for cell dynamic analysis. Microfluidics provides the potential for reproducing and controlling spatio-temporal biochemical signals through the various microfluidic channels. Herein we investigate the transmission characteristics of dynamic biochemical signals in pulsatile flows by analytically solving the convection–diffusion equation for the time-dependent Taylor–Aris dispersion with perturbation method. We prove that the transmission of dynamic biochemical signals in pulsatile flows is subject to the two correlate effects: low-pass filtering and nonlinear amplitude–frequency modulation. These two effects are systematically characterized and the influence factors are studied, including the biochemical signal frequency, the pulsatile flow frequency, the transmission distance and the average pulsatile flow rate. We concluded that the balance of multiple factors should be taken into account for better loading biochemical signals on cells cultured in the microfluidic channel. |
| ArticleNumber | 81 |
| Author | Cao, Tun Qin, Kai-Rong Li, Yong-Jiang |
| Author_xml | – sequence: 1 givenname: Yong-Jiang surname: Li fullname: Li, Yong-Jiang organization: School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology – sequence: 2 givenname: Tun surname: Cao fullname: Cao, Tun email: caotun1806@dlut.edu.cn organization: School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology – sequence: 3 givenname: Kai-Rong orcidid: 0000-0001-6781-2941 surname: Qin fullname: Qin, Kai-Rong email: krqin@dlut.edu.cn organization: School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Department of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology |
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| CitedBy_id | crossref_primary_10_1007_s10404_022_02542_2 crossref_primary_10_1088_1361_6439_ab9e4e crossref_primary_10_1039_D0LC01297A crossref_primary_10_1140_epje_i2019_11793_y crossref_primary_10_1007_s10404_019_2283_1 crossref_primary_10_1007_s10404_023_02623_w crossref_primary_10_3390_mi12020161 crossref_primary_10_1002_elps_202200104 crossref_primary_10_1016_j_talanta_2023_125172 |
| Cites_doi | 10.1152/ajpendo.00248.2011 10.1021/acs.analchem.7b01967 10.1038/31960 10.1126/science.1110542 10.1007/s10404-004-0013-8 10.1007/s125-002-8240-x 10.1371/journal.pone.0004847 10.1039/b718376c 10.1016/j.plrev.2017.06.016 10.3390/mi7110213 10.1039/b909312e 10.1126/science.1151582 10.1146/annurev.bioeng.9.060906.151850 10.1038/nature07211 10.1016/1043-2760(92)90169-2 10.1007/s00216-007-1564-9 10.1016/j.mcm.2006.11.029 10.1007/s10237-010-0270-2 10.1039/b716634f 10.1021/ac101461x 10.1038/nature05063 10.1007/s11433-013-4991-y 10.1115/1.4025774 10.1007/s13206-011-5304-z 10.1021/ac025536c 10.1039/C7AN01346A 10.1371/journal.pone.0014624 10.1242/jcs.109.4.713 |
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| References | Malek, Izumo (CR14) 1996; 109 Oppenheim, Willsky, Hamid (CR18) 1996 Zhang, Daou, Truong, Bertram, Roper (CR29) 2011; 301 Zhu, Li, Qin, Tang, Qiu (CR30) 2013; 56 Lam, Chen, Yang (CR12) 2005; 1 Swartz, Fleury (CR24) 2007; 9 Mettetal, Muzzey, Gomez-Uribe, Oudenaarden (CR15) 2008; 319 Chen, Yuan, Aziz, Gao, Zeng, Liu, Qin (CR5) 2017; 38 Dolmetsch, Xu, Lewis (CR8) 1998; 392 Kuczenski, Ruder, Messner, Leduc (CR11) 2009; 4 Chen, Gao, Zeng, Liu, Luan, Qin (CR4) 2016; 7 Zhang, Yin, Cooper, Haswell (CR27) 2008; 390 Zhang, Grimley, Bertram, Roper (CR28) 2010; 82 Kim, Joshi, Messner, Leduc, Davidson (CR10) 2011; 6 Shao, Wu, Wu, Zheng, Zhao, Jin, Zhao (CR22) 2009; 9 Bennett, Pang, Ostroff, Baumgartner, Nayak, Tsimring, Hasty (CR2) 2008; 454 Moore, Lemischka (CR16) 2006; 311 Brabant, Prank, Schofl (CR3) 1992; 3 Yang, Li, Yang (CR26) 2002; 74 Qin, Xiang, Cao (CR21) 2011; 10 Li, Li, Cao, Qin (CR13) 2013; 135 Cheng, Lin, Huang, Li, Ji, Genin, Deshpande, Lu, Xu (CR7) 2017; 22–23 Murphy, Zhang, Naler, Ma, Lu (CR17) 2018; 143 Parks, Romero (CR19) 2007; 46 El-Ali, Sorger, Jensen (CR9) 2006; 442 Shin, Mahto, Kim, Rhee (CR23) 2011; 5 Azizi, Mastrangelo (CR1) 2008; 8 Xie, Wang, Chen, Mastrangelo (CR25) 2008; 8 Porksen (CR20) 2002; 45 Chen, Guo, Feng, Yan, Wang, Li, Du, Liu (CR6) 2017; 89 YT Kim (2097_CR10) 2011; 6 B Kuczenski (2097_CR11) 2009; 4 P Chen (2097_CR6) 2017; 89 M Yang (2097_CR26) 2002; 74 J El-Ali (2097_CR9) 2006; 442 J Shao (2097_CR22) 2009; 9 Y Zhu (2097_CR30) 2013; 56 YJ Li (2097_CR13) 2013; 135 JT Mettetal (2097_CR15) 2008; 319 ML Parks (2097_CR19) 2007; 46 Y Xie (2097_CR25) 2008; 8 TW Murphy (2097_CR17) 2018; 143 KR Qin (2097_CR21) 2011; 10 AV Oppenheim (2097_CR18) 1996 RE Dolmetsch (2097_CR8) 1998; 392 X Zhang (2097_CR27) 2008; 390 MA Swartz (2097_CR24) 2007; 9 ZZ Chen (2097_CR5) 2017; 38 MR Bennett (2097_CR2) 2008; 454 N Porksen (2097_CR20) 2002; 45 H Shin (2097_CR23) 2011; 5 AM Malek (2097_CR14) 1996; 109 G Brabant (2097_CR3) 1992; 3 F Azizi (2097_CR1) 2008; 8 ZZ Chen (2097_CR4) 2016; 7 X Zhang (2097_CR28) 2010; 82 B Cheng (2097_CR7) 2017; 22–23 YC Lam (2097_CR12) 2005; 1 X Zhang (2097_CR29) 2011; 301 KA Moore (2097_CR16) 2006; 311 |
| References_xml | – year: 1996 ident: CR18 publication-title: Signals and systems – volume: 301 start-page: E742 year: 2011 ident: CR29 article-title: Synchronization of mouse islets of Langerhans by glucose waveforms publication-title: AJP Endocrinol Metab doi: 10.1152/ajpendo.00248.2011 – volume: 89 start-page: 9209 year: 2017 ident: CR6 article-title: A microfluidic chemical function generator for probing dynamic cell signaling publication-title: Anal Chem doi: 10.1021/acs.analchem.7b01967 – volume: 392 start-page: 933 year: 1998 ident: CR8 article-title: Calcium oscillations increase the efficiency and specificity of gene expression publication-title: Nature doi: 10.1038/31960 – volume: 311 start-page: 1880 issue: 5769 year: 2006 ident: CR16 article-title: Stem cells and their niches publication-title: Science doi: 10.1126/science.1110542 – volume: 1 start-page: 218 year: 2005 ident: CR12 article-title: Depthwise averaging approach to cross-stream mixing in a pressure-driven microchannel flow publication-title: Microfluid Nanofluid doi: 10.1007/s10404-004-0013-8 – volume: 45 start-page: 3 year: 2002 ident: CR20 article-title: The in vivo regulation of pulsatile insulin secretion publication-title: Diabetologia doi: 10.1007/s125-002-8240-x – volume: 4 start-page: e4847 issue: 3 year: 2009 ident: CR11 article-title: Probing cellular dynamics with a chemical signal generator publication-title: Plos One doi: 10.1371/journal.pone.0004847 – volume: 8 start-page: 779 year: 2008 ident: CR25 article-title: Fourier microfluidics publication-title: Lab Chip doi: 10.1039/b718376c – volume: 22–23 start-page: 88 year: 2017 ident: CR7 article-title: Cellular mechanosensing of the biophysical microenvironment: a review of mathematical models of biophysical regulation of cell responses publication-title: Phys Life Rev doi: 10.1016/j.plrev.2017.06.016 – volume: 7 start-page: 213 year: 2016 ident: CR4 article-title: A Y-shaped microfluidic device to study the combined effect of wall shear stress and ATP signals on intracellular calcium dynamics in vascular endothelial cells publication-title: Micromachines doi: 10.3390/mi7110213 – volume: 9 start-page: 3118 year: 2009 ident: CR22 article-title: Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress publication-title: Lab Chip doi: 10.1039/b909312e – volume: 319 start-page: 482 year: 2008 ident: CR15 article-title: The frequency dependence of osmo-adaptation in publication-title: Science doi: 10.1126/science.1151582 – volume: 9 start-page: 229 year: 2007 ident: CR24 article-title: Interstitial flow and its effects in soft tissues publication-title: Annu Rev Biomed Eng doi: 10.1146/annurev.bioeng.9.060906.151850 – volume: 454 start-page: 1119 year: 2008 ident: CR2 article-title: Metabolic gene regulation in a dynamically changing environment publication-title: Nature doi: 10.1038/nature07211 – volume: 3 start-page: 183 issue: 5 year: 1992 ident: CR3 article-title: Pulsatile pattern in hormone secretion publication-title: Trends Endocrinol Metab doi: 10.1016/1043-2760(92)90169-2 – volume: 390 start-page: 833 issue: 3 year: 2008 ident: CR27 article-title: Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques publication-title: Anal Bioanal Chem doi: 10.1007/s00216-007-1564-9 – volume: 46 start-page: 699 year: 2007 ident: CR19 article-title: Taylor–Aris dispersion in high aspect ratio columns of nearly rectangular cross section publication-title: Math Comput Model doi: 10.1016/j.mcm.2006.11.029 – volume: 10 start-page: 743 issue: 5 year: 2011 ident: CR21 article-title: Dynamic modeling for flow-activated chloride-selective membrane current in vascular endothelial cells publication-title: Biomech Model Mechanobiol doi: 10.1007/s10237-010-0270-2 – volume: 8 start-page: 907 issue: 6 year: 2008 ident: CR1 article-title: Generation of dynamic chemical signals with pulse code modulators publication-title: Lab Chip doi: 10.1039/b716634f – volume: 82 start-page: 6704 year: 2010 ident: CR28 article-title: Microfluidic system for generation of sinusoidal glucose waveforms for entrainment of Islets of Langerhans publication-title: Anal Chem doi: 10.1021/ac101461x – volume: 442 start-page: 403 year: 2006 ident: CR9 article-title: Cells on chips publication-title: Nature doi: 10.1038/nature05063 – volume: 56 start-page: 322 year: 2013 ident: CR30 article-title: Transportation of dynamic biochemical signals in non-reversing oscillatory flows in blood vessels publication-title: Sci China Phys Mech Astron doi: 10.1007/s11433-013-4991-y – volume: 135 start-page: 121011 year: 2013 ident: CR13 article-title: Transport of dynamic biochemical signals in steady flow in a shallow Y-shaped microfluidic channel: effect of transverse diffusion and longitudinal dispersion publication-title: J Biomech Eng doi: 10.1115/1.4025774 – volume: 5 start-page: 214 issue: 3 year: 2011 ident: CR23 article-title: Exposure of BALB/3T3 fibroblast cells to temporal concentration profile of toxicant inside microfluidic device publication-title: Biochip J doi: 10.1007/s13206-011-5304-z – volume: 74 start-page: 3991 year: 2002 ident: CR26 article-title: Cell docking and on-chip monitoring of cellular reactions with a controlled concentration gradient on a microfluidic device publication-title: Anal Chem doi: 10.1021/ac025536c – volume: 38 start-page: 1 issue: 10 year: 2017 ident: CR5 article-title: Transfer characteristics of dynamic biochemical signals in non-reversing pulsatile flows in a shallow Y-shaped microfluidic channel: signal filtering and nonlinear amplitude-frequency modulation publication-title: Appl Math Mech – volume: 143 start-page: 60 year: 2018 ident: CR17 article-title: Recent advances on microfluidic technologies for single cell analysis publication-title: Analyst doi: 10.1039/C7AN01346A – volume: 6 start-page: e14624 issue: 1 year: 2011 ident: CR10 article-title: Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue publication-title: Plos One doi: 10.1371/journal.pone.0014624 – volume: 109 start-page: 713 issue: 2 year: 1996 ident: CR14 article-title: Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress publication-title: J Cell Sci – volume: 7 start-page: 213 year: 2016 ident: 2097_CR4 publication-title: Micromachines doi: 10.3390/mi7110213 – volume: 1 start-page: 218 year: 2005 ident: 2097_CR12 publication-title: Microfluid Nanofluid doi: 10.1007/s10404-004-0013-8 – volume: 3 start-page: 183 issue: 5 year: 1992 ident: 2097_CR3 publication-title: Trends Endocrinol Metab doi: 10.1016/1043-2760(92)90169-2 – volume: 143 start-page: 60 year: 2018 ident: 2097_CR17 publication-title: Analyst doi: 10.1039/C7AN01346A – volume: 8 start-page: 779 year: 2008 ident: 2097_CR25 publication-title: Lab Chip doi: 10.1039/b718376c – volume: 390 start-page: 833 issue: 3 year: 2008 ident: 2097_CR27 publication-title: Anal Bioanal Chem doi: 10.1007/s00216-007-1564-9 – volume: 135 start-page: 121011 year: 2013 ident: 2097_CR13 publication-title: J Biomech Eng doi: 10.1115/1.4025774 – volume: 4 start-page: e4847 issue: 3 year: 2009 ident: 2097_CR11 publication-title: Plos One doi: 10.1371/journal.pone.0004847 – volume-title: Signals and systems year: 1996 ident: 2097_CR18 – volume: 89 start-page: 9209 year: 2017 ident: 2097_CR6 publication-title: Anal Chem doi: 10.1021/acs.analchem.7b01967 – volume: 6 start-page: e14624 issue: 1 year: 2011 ident: 2097_CR10 publication-title: Plos One doi: 10.1371/journal.pone.0014624 – volume: 82 start-page: 6704 year: 2010 ident: 2097_CR28 publication-title: Anal Chem doi: 10.1021/ac101461x – volume: 5 start-page: 214 issue: 3 year: 2011 ident: 2097_CR23 publication-title: Biochip J doi: 10.1007/s13206-011-5304-z – volume: 74 start-page: 3991 year: 2002 ident: 2097_CR26 publication-title: Anal Chem doi: 10.1021/ac025536c – volume: 22–23 start-page: 88 year: 2017 ident: 2097_CR7 publication-title: Phys Life Rev doi: 10.1016/j.plrev.2017.06.016 – volume: 109 start-page: 713 issue: 2 year: 1996 ident: 2097_CR14 publication-title: J Cell Sci doi: 10.1242/jcs.109.4.713 – volume: 319 start-page: 482 year: 2008 ident: 2097_CR15 publication-title: Science doi: 10.1126/science.1151582 – volume: 45 start-page: 3 year: 2002 ident: 2097_CR20 publication-title: Diabetologia doi: 10.1007/s125-002-8240-x – volume: 10 start-page: 743 issue: 5 year: 2011 ident: 2097_CR21 publication-title: Biomech Model Mechanobiol doi: 10.1007/s10237-010-0270-2 – volume: 301 start-page: E742 year: 2011 ident: 2097_CR29 publication-title: AJP Endocrinol Metab doi: 10.1152/ajpendo.00248.2011 – volume: 311 start-page: 1880 issue: 5769 year: 2006 ident: 2097_CR16 publication-title: Science doi: 10.1126/science.1110542 – volume: 392 start-page: 933 year: 1998 ident: 2097_CR8 publication-title: Nature doi: 10.1038/31960 – volume: 442 start-page: 403 year: 2006 ident: 2097_CR9 publication-title: Nature doi: 10.1038/nature05063 – volume: 46 start-page: 699 year: 2007 ident: 2097_CR19 publication-title: Math Comput Model doi: 10.1016/j.mcm.2006.11.029 – volume: 8 start-page: 907 issue: 6 year: 2008 ident: 2097_CR1 publication-title: Lab Chip doi: 10.1039/b716634f – volume: 56 start-page: 322 year: 2013 ident: 2097_CR30 publication-title: Sci China Phys Mech Astron doi: 10.1007/s11433-013-4991-y – volume: 9 start-page: 229 year: 2007 ident: 2097_CR24 publication-title: Annu Rev Biomed Eng doi: 10.1146/annurev.bioeng.9.060906.151850 – volume: 454 start-page: 1119 year: 2008 ident: 2097_CR2 publication-title: Nature doi: 10.1038/nature07211 – volume: 38 start-page: 1 issue: 10 year: 2017 ident: 2097_CR5 publication-title: Appl Math Mech – volume: 9 start-page: 3118 year: 2009 ident: 2097_CR22 publication-title: Lab Chip doi: 10.1039/b909312e |
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| SubjectTerms | Analytical Chemistry Biochemistry Biomedical Engineering and Bioengineering Cells Convection Dye dispersion Dynamic analysis Engineering Engineering Fluid Dynamics Flow rates Flow velocity Frequency dependence Frequency modulation Low pass filters Mathematical models Microfluidics Nanotechnology and Microengineering Perturbation method Perturbation methods Research Paper Time dependence |
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| Title | Transmission of dynamic biochemical signals in the shallow microfluidic channel: nonlinear modulation of the pulsatile flow |
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