Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment

• Published in: Pharmaceutical development and technology Vol. 2; no. 3; p. 243
• Main Authors: Sabnis, S, Rege, P, Block, L H
• Format: Journal Article
• Language: English
• Published: England 1997
• Subjects: Acids; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Biocompatible Materials; Chitin - analogs & derivatives; Chitosan; Compressive Strength; Diclofenac - pharmacokinetics; Microscopy, Electron, Scanning; Molecular Weight; Polymers; Solubility; Tablets; X-Ray Diffraction

The purpose of this study was to evaluate the potential utility of chitosan (I) in inhibiting diclofenac sodium (II) release in the gastric environment from a directly compressible tablet formulation. I, subjected to depolymerization to improve its microcrystallinity and subsequent compressibility,...