In vivo evaluation for rhGM-CSF wound-healing efficacy in topical vehicles

• Published in: Pharmaceutical development and technology Vol. 2; no. 2; p. 171
• Main Authors: Memişoğlu, E, Oner, F, Ayhan, A, Başaran, I, Hincal, A A
• Format: Journal Article
• Language: English
• Published: England 1997
• Subjects: Animals; Emulsions; Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage; Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use; Humans; Mice; Pharmaceutical Vehicles; Recombinant Proteins; Skin - injuries; Skin - pathology; Spectrophotometry, Ultraviolet; Wound Healing - drug effects; Wounds and Injuries - pathology

The wound-healing efficacy of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) was studied in a mouse model. Full-thickness wounds were treated with liquid crystalline, emulsion, and niosome vehicles alone and with rhGM-CSF. The control group was non-medicated. Observati...