Experimental and theoretical investigation of new furan and thiophene derivatives containing oxazole, isoxazole, or isothiazole subunits

• Published in: Structural chemistry Vol. 28; no. 3; pp. 773 - 790
• Main Authors: Civcir, Pervin Ünal, Kurtay, Gülbin, Sarıkavak, Kübra
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2017; Springer Nature B.V
• Subjects: Chemical synthesis; Chemistry; Chemistry and Materials Science; Computer Applications in Chemistry; Energy gap; Original Research; Physical Chemistry; Theoretical and Computational Chemistry; Isoxazole; Isothiazole; Furan; DFT; Thiophene; Oxazole

Herein, we present joint experimental and theoretical studies on newly designed thiophene- or furan-based oxazole, isoxazole, and isothiazole derivatives. Our synthetic approach towards the preparation of target compounds is based on Van Leusen reaction. By following this reaction, oxazoles ( 1 and...