Statin therapy increases lipoprotein(a) levels

• Published in: European heart journal Vol. 41; no. 24; pp. 2275 - 2284
• Main Authors: Tsimikas, Sotirios, Gordts, Philip L S M, Nora, Chelsea, Yeang, Calvin, Witztum, Joseph L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 21.06.2020
• Subjects: Atorvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoprotein(a); Pravastatin - therapeutic use; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Assay; Aortic stenosis; Cardiovascular disease; Lipoprotein(a)

Abstract Aims Lipoprotein(a) [Lp(a)] is elevated in 20–30% of people. This study aimed to assess the effect of statins on Lp(a) levels. Methods and results This subject-level meta-analysis includes 5256 patients (1371 on placebo and 3885 on statin) from six randomized trials, three statin-vs.-placeb...