High-Capacity Calcium Carbonate Particles As pH-Sensitive Containers for Doxorubicin

Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO 3 :Si:Fe nanoparticles 65 ±...

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Published inCrystallography reports Vol. 68; no. 2; pp. 309 - 315
Main Authors Pallaeva, T. N., Mikheev, A. V., Khmelenin, D. N., Eurov, D. A., Kurdyukov, D. A., Popova, V. K., Dmitrienko, E. V., Trushina, D. B.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2023
Springer Nature B.V
Subjects
Aqueous solutions
Calcium carbonate
Crystal structure
Crystallization
Crystallography and Scattering Methods
Doxorubicin
Iron
Nanomaterials and Ceramics
Nanoparticles
Physics
Physics and Astronomy
Polyethylene glycol
Polymorphism
Silicon
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Summary:Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO 3 :Si:Fe nanoparticles 65 ± 15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent, as well as its release under model conditions at different рН, is determined.
ISSN:1063-7745
1562-689X
DOI:10.1134/S1063774523020128