The adjuvant effect of selenium nanoparticles, Triton X-114 detergent micelles, and lecithin liposomes for Escherichia coli antigens
We studied the adjuvant properties of micelles from nonionogenic detergents, liposome, and selenium nanoparticles containing extracellular and intracellular vaccine antigens of a weakly virulent α-hemolytic Escherichia coli B-5 strain used for the immunization of experimental animals. Triton X-100 w...
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Published in | Applied biochemistry and microbiology Vol. 53; no. 5; pp. 587 - 593 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Moscow
Pleiades Publishing
01.09.2017
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | We studied the adjuvant properties of micelles from nonionogenic detergents, liposome, and selenium nanoparticles containing extracellular and intracellular vaccine antigens of a weakly virulent α-hemolytic
Escherichia coli
B-5 strain used for the immunization of experimental animals. Triton X-100 was used as a nonionogenic detergent for micelle preparation. The liposomes were obtained on the basis of lecithin from a chicken egg and
E. coli
B-5 membrane lipids. Native lipoproteins of
E. coli
B-5 cells and peptides for the proteolytic hydrolysis of toxin-containing culture liquid were used as antigens for micelles and liposomes. The obtained data suggested that micelles, liposomes, and selenium nanoparticles can be used for immunization with cellular and extracellular
E. coli
antigens. |
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ISSN: | 0003-6838 1608-3024 |
DOI: | 10.1134/S0003683817050040 |