TGF beta promotes the basal phenotype of epidermal keratinocytes: transcriptional induction of K#5 and K#14 keratin genes

• Published in: Growth factors (Chur, Switzerland) Vol. 12; no. 2; p. 87
• Main Authors: Jiang, C K, Tomić-Canić, M, Lucas, D J, Simon, M, Blumenberg, M
• Format: Journal Article
• Language: English
• Published: England 1995
• Subjects: 3T3 Cells; Animals; Cattle; Cells, Cultured; Epidermis; HeLa Cells; Humans; Keratinocytes - metabolism; Keratins - genetics; Mice; Phenotype; Promoter Regions, Genetic; Transcription, Genetic; Transfection; Transforming Growth Factor beta - pharmacology

TGFbeta is an important regulator of epidermal keratinocyte function because it suppresses cell proliferation, while it induces synthesis of extracellular matrix proteins and their cells surface receptors. To examine whether TGFbeta affects synthesis of intracellular proteins as well, specifically t...