A short review of cognitive and functional neuroimaging studies of cholinergic drugs: implications for therapeutic potentials

• Published in: Journal of Neural Transmission Vol. 109; no. 5-6; pp. 857 - 870
• Main Authors: Freo, U, Pizzolato, G, Dam, M, Ori, C, Battistin, L
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.05.2002
• Subjects: Alzheimer Disease - psychology; Animals; Brain - diagnostic imaging; Brain - physiology; Cerebrovascular Circulation - drug effects; Cholinergic Agents - pharmacology; Cholinergic Agents - therapeutic use; Cognition - drug effects; Cognition - physiology; Humans; Memory - drug effects; Memory Disorders - drug therapy; Radiography; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

In the last 20 years a cholinergic dysfunction has been the major working hypothesis for the pharmacology of memory disorders. Cholinergic antagonists and lesions impair and different classes of cholinomimetics (i.e. acetylcholine precursors, cholinergic agonists and acetylcholinesterase inhibitors)...