Antithrombotic treatment of ischemic stroke among patients with occlusion or severe stenosis of the internal carotid artery: A report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST)

• Published in: Neurology Vol. 53; no. 1; p. 122
• Main Authors: Adams, Jr, H P, Bendixen, B H, Leira, E, Chang, K C, Davis, P H, Woolson, R F, Clarke, W R, Hansen, M D
• Format: Journal Article
• Language: English
• Published: United States 13.07.1999
• Subjects: Anticoagulants - therapeutic use; Brain Ischemia - complications; Brain Ischemia - diagnostic imaging; Brain Ischemia - drug therapy; Carotid Artery, Internal - diagnostic imaging; Carotid Stenosis - complications; Carotid Stenosis - diagnostic imaging; Chondroitin Sulfates - therapeutic use; Dermatan Sulfate - therapeutic use; Double-Blind Method; Drug Combinations; Female; Fibrinolytic Agents - therapeutic use; Functional Laterality; Glasgow Coma Scale; Heparitin Sulfate - therapeutic use; Humans; Male; Placebos; Time Factors; Trauma Severity Indices; Treatment Outcome; Ultrasonography, Doppler, Duplex

To examine the responses to early IV administration of an anticoagulant or placebo started within 24 hours of stroke among persons with an ipsilateral occlusion or severe stenosis of the internal carotid artery (ICA) identified by carotid duplex imaging. Patients with ischemic stroke of the cerebral...