Age-related changes in microcirculation in the cortex of hypertonic rats

We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the co...

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Published inAdvances in gerontology Vol. 7; no. 1; pp. 51 - 55
Main Authors Sokolova, I. B., Sergeev, I. V., Fedotova, O. R., Melnikova, N. N., Dvoretsky, D. P.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 2017
Springer Nature B.V
Subjects
Age
Aging
Animals
Blood pressure
Blood vessels
Geriatrics/Gerontology
Gerontology
Hypertension
Medicine
Medicine & Public Health
Oxygen saturation
Statistical analysis
Veins & arteries
perfusion
aging
brain
behavior
hypertension
microcirculation
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Abstract We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.
AbstractList We have studied the density of the microvascular system of the pia matter and perfusion and oxygen saturation of the sensorimotor cortex in hypertonic rats of different ages. We have found that the density of the microvascular system did not decrease, but increased, with age. The perfusion of the cortex decreased, and oxygen saturation of brain tissues increased. By the age of 12 months, the exploratory behavior of rats in an open-field test worsened significantly by all parameters.
Author Dvoretsky, D. P.
Melnikova, N. N.
Sergeev, I. V.
Sokolova, I. B.
Fedotova, O. R.
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10.1134/S1990519X14040105
10.1161/STROKEAHA.107.495457
10.1212/01.WNL.0000158283.28251.3C
10.1016/j.cmet.2008.03.010
10.1002/ar.21184
10.1161/hs0901.094282
10.1016/j.neuroimage.2007.05.024
10.1007/s11055-010-9318-0
10.1111/j.1365-2990.2010.01139.x
10.1002/hbm.20574
10.1134/S2079057016010124
10.1111/j.1750-3639.2002.tb00450.x
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Keywords perfusion
aging
brain
behavior
hypertension
microcirculation
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SubjectTerms Age
Aging
Animals
Blood pressure
Blood vessels
Geriatrics/Gerontology
Gerontology
Hypertension
Medicine
Medicine & Public Health
Oxygen saturation
Statistical analysis
Veins & arteries
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Title Age-related changes in microcirculation in the cortex of hypertonic rats
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