A step-by-step multiple stimuli-responsive metal-phenolic network prodrug nanoparticles for chemotherapy

• Published in: Nano research Vol. 15; no. 2; pp. 1205 - 1212
• Main Authors: Yi, Xiaoqing, Zeng, Weijia, Wang, Cui, Chen, Ying, Zheng, Liangyuan, Zhu, Xinlin, Ke, Yuqiu, He, Xiaoyan, Kuang, Ying, Huang, Qitong
• Format: Journal Article
• Language: English
• Published: Beijing Tsinghua University Press 01.02.2022
• Subjects: Atomic/Molecular Structure and Spectra; Bioavailability; Biocompatibility; Biomedicine; Biotechnology; Chemistry and Materials Science; Chemotherapy; Condensed Matter Physics; Doxorubicin; Drug delivery; Drug delivery systems; Iron; Materials Science; Nanoparticles; Nanotechnology; Organs; Paclitaxel; Phenolic compounds; Phenols; Prodrugs; Research Article; Side effects; Stability; Stimuli; Tannic acid; Toxicity; Tumor cells; Tumors; step-by-step multiple stimuli-responsive; superior stability; metal-phenolic network; drug delivery

Currently, chemotherapy is the main clinical therapy of tumors. Depressingly, most chemotherapeutic drugs such as doxorubicin and paclitaxel (PTX) have poor water solubility, leading to low bioavailability and serious side effects. Till now, although a variety of nanoparticulate drug delivery system...