Phospholipase A2 activity is associated with structural brain changes in schizophrenia

• Published in: NeuroImage (Orlando, Fla.) Vol. 52; no. 4; pp. 1314 - 1327
• Main Authors: Smesny, Stefan, Milleit, Berko, Nenadic, Igor, Preul, Christoph, Kinder, Daniel, Lasch, Jürgen, Willhardt, Ingo, Sauer, Heinrich, Gaser, Christian
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2010; Elsevier Limited
• Subjects: Adult; Attention deficit hyperactivity disorder; Biomarkers - blood; Brain; Brain - pathology; Enzymes; Female; Gray matter; Humans; Imaging; Magnetic Resonance Imaging; Male; Marker; Membrane lipids; Middle Aged; Morphometry; MRI; Oxidative stress; Phospholipases A2 - blood; Phospholipids; Psychotropic drugs; Schizophrenia; Schizophrenia - blood; Schizophrenia - pathology; Studies; White matter; Membrane lipids; MRI; Imaging; Schizophrenia; Phospholipids; Marker; Morphometry; Gray matter; White matter

Regional structural brain changes are among the most robust biological findings in schizophrenia, yet the underlying pathophysiological changes remain poorly understood. Recent evidence suggests that abnormal neuronal/dendritic plasticity is related to alterations in membrane lipids. We examined whe...