Label-free cell-based assays using photonic crystal optical biosensors

• Published in: Analyst (London) Vol. 136; no. 6; pp. 1090 - 1102
• Main Authors: Shamah, Steven M., Cunningham, Brian T.
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 21.03.2011
• Subjects: Ageing, cell death; Analytical chemistry; Applied sciences; Biological and medical sciences; Biosensing Techniques - instrumentation; Biosensing Techniques - methods; Biosensors; Biotechnology; Cell physiology; Cells - metabolism; Chemistry; Cytological Techniques; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; General, instrumentation; Global environmental pollution; Methods. Procedures. Technologies; Molecular and cellular biology; Optics and Photonics - instrumentation; Optics and Photonics - methods; Pollution; Reproducibility of Results; Sensitivity and Specificity; Various methods and equipments; Cell proliferation; Membrane protein; Chemical analysis; Use; Instrumentation; Cytotoxicity; Molecular interaction; Activation; Ionic channel; Time; Review; Chemical sensor; Chemotaxis; Transducer; Molecular evolution; Regulation(control); Microscopy; Cell death; Biosensor; Environment; Detection; Application; Monitoring; Apoptosis

Biosensor technologies that have been primarily used in the past for characterizing biomolecular interactions are now being used to develop new approaches for performing cell-based assays. Biosensors monitor cell attachment to a transducer surface, and thus provide information that is fundamentally...