Immunogenicity of viral B- and T-cell epitopes expressed in recombinant bacterial proteins

• Published in: International reviews of immunology Vol. 11; no. 2; p. 123
• Main Authors: Leclerc, C, Lo-Man, R, Charbit, A, Martineau, P, Clément, J M, Hofnung, M
• Format: Journal Article
• Language: English
• Published: England 1994
• Subjects: Amino Acid Sequence; Antigens - immunology; ATP-Binding Cassette Transporters; B-Lymphocytes - immunology; Bacterial Outer Membrane Proteins; Bacterial Proteins - immunology; Carrier Proteins - immunology; Epitopes - immunology; Escherichia coli Proteins; Maltose-Binding Proteins; Molecular Sequence Data; Monosaccharide Transport Proteins; Periplasmic Binding Proteins; Porins; Protein Conformation; Receptors, Virus - immunology; Recombinant Fusion Proteins - immunology; T-Lymphocytes - immunology; Viral Proteins - immunology

Foreign polypeptides can be expressed as genetic inserts in several permissive sites of MalE and LamB, two Escherichia coli envelope proteins. Several viral B and T-cell epitopes have been inserted in these proteins and we analyzed the role of the molecular environment on the immunogenicity of the f...