Chemistry of the shellfish toxin domoic acid: characterization of related compounds

• Published in: Canadian journal of chemistry Vol. 72; no. 2; pp. 430 - 436
• Main Authors: Walter, John A, Falk, Michael, Wright, Jeffrey L.C
• Format: Journal Article
• Language: English
• Published: Ottawa, Canada NRC Research Press 01.02.1994; National Research Council of Canada
• Subjects: Analytical, structural and metabolic biochemistry; Aromatic and heterocyclic compounds; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Heterocyclic compounds, pigments; Other biological molecules; Five membered ring; Shellfish; Molecular structure; Nitrogen heterocycle; Neurotoxin; Isolation; NMR spectrum; Ethylenic compound; Pyrrolidine derivatives; Conformation; Tricarboxylic acid

Five new compounds related to the neurotoxin domoic acid have been characterized by spectroscopic methods. They include a diastereoisomer that occurs naturally with domoic acid in mussels and four hydrogenation products. The stereochemistry of the two epimeric tetrahydro derivatives could not be ass...